Stephen Fesik: search on Z-Library

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1

Twenty years on: the impact of fragments on drug discovery

Erlanson, Daniel A., Fesik, Stephen W., Hubbard, Roderick E., Jahnke, Wolfgang, Jhoti, Harren

Journal:

Nature Reviews Drug Discovery

Year:

2016

Language:

english

File:

PDF, 3.52 MB

english, 2016

2

Privileged Molecules for Protein Binding Identified from NMR-Based Screening

Hajduk, Philip J., Bures, Mark, Praestgaard, Jens, Fesik, Stephen W.

Journal:

Journal of Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 66 KB

english, 2000

3

High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling

Burns, Michael C., Howes, Jennifer E., Sun, Qi, Little, Andrew J., Camper, DeMarco V., Abbott, Jason R., Phan, Jason, Lee, Taekyu, Waterson, Alex G., Rossanese, Olivia W., Fesik, Stephen W.

Journal:

Analytical Biochemistry

Year:

2018

Language:

english

File:

PDF, 1.33 MB

english, 2018

4

Promoting apoptosis as a strategy for cancer drug discovery

Fesik, Stephen W.

Journal:

Nature Reviews Cancer

Year:

2005

Language:

english

File:

PDF, 608 KB

english, 2005

5

Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation

Qi Sun, Dr. Jason P. Burke, Prof. Jason Phan, Michael C. Burns, Prof. Edward T. Olejniczak, Prof. Alex G. Waterson, Prof. Taekyu Lee, Prof. Olivia W. Rossanese, Prof. Stephen W. Fesik

Journal:

Angewandte Chemie

Year:

2012

Language:

english

File:

PDF, 1.36 MB

english, 2012

6

Drugging the undruggable RAS: Mission Possible?

Cox, Adrienne D., Fesik, Stephen W., Kimmelman, Alec C., Luo, Ji, Der, Channing J.

Journal:

Nature Reviews Drug Discovery

Year:

2014

Language:

english

File:

PDF, 1.40 MB

english, 2014

7

10.1038/44617

Fesik, Stephen W., Sun, Chaohong, Cai, Mengli, Gunasekera, Angelo H., Meadows, Robert P., Wang, Hong, Chen, Jun, Zhang, Haichao, Wu, Wei, Xu, Nan, Ng, Shi-Chung

Journal:

Year:

1999

Language:

english

File:

PDF, 405 KB

english, 1999

8

Synthesis of [u-13C,15N]-cysteine hydrochloride: An important tool for heteronuclear, multi-dimensional NMR studies of proteins

Michael J. Panigot, Stephen W. Fesik, Robert W. Curley Jr.

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Year:

1995

Language:

english

File:

PDF, 310 KB

english, 1995

9

Rationale for Bcl-XL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies

Andrew M. Petros, David G. Nettesheim, Yi Wang, Edward T. Olejniczak, Robert P. Meadows, Jamey Mack, Kerry Swift, Edmund D. Matayoshi, Haichao Zhang, Stephen W. Fesik, Craig B. Thompson

Journal:

Protein Science

Year:

2000

Language:

english

File:

PDF, 2.75 MB

english, 2000

10

Novel p -Arylthio Cinnamides as Antagonists of Leukocyte Function-Associated Antigen-1/Intracellular Adhesion Molecule-1 Interaction. 2. Mechanism of Inhibition and Structure-Based Improvement of Pharmaceutical Properties

Liu, Gang, Huth, Jeffrey R., Olejniczak, Edward T., Mendoza, Renaldo, DeVries, Peter, Leitza, Sandra, Reilly, Edward B., Okasinski, Gregory F., Fesik, Stephen W., von Geldern, Thomas W.

Journal:

Journal of Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 440 KB

english, 2001

11

NMR-Based Screening of Proteins Containing 13 C-Labeled Methyl Groups

Hajduk, Philip J., Augeri, David J., Mack, Jamey, Mendoza, Renaldo, Yang, Jianguo, Betz, Stephen F., Fesik, Stephen W.

Journal:

Journal of the American Chemical Society

Year:

2000

Language:

english

File:

PDF, 162 KB

english, 2000

12

Structure of the N-Terminal RNA-Binding Domain of the SARS CoV Nucleocapsid Protein

Huang, Qiulong, Yu, Liping, Petros, Andrew M., Gunasekera, Angelo, Liu, Zhihong, Xu, Nan, Hajduk, Philip, Mack, Jamey, Fesik, Stephen W., Olejniczak, Edward T.

Journal:

Year:

2004

Language:

english

File:

PDF, 186 KB

english, 2004

13

Methoxy group conformations of phenyl methyl ethers in solution

Makriyannis, Alexandros, Fesik, Stephen

Journal:

Journal of the American Chemical Society

Year:

1982

Language:

english

File:

PDF, 291 KB

english, 1982

14

Solution Structure of the Cytohesin-1 (B2-1) Sec7 Domain and Its Interaction with the GTPase ADP Ribosylation Factor 1

Stephen F. Betz, Arndt Schnuchel, Hong Wang, Edward T. Olejniczak, Robert P. Meadows, Brian P. Lipsky, Edith A. S. Harris, Donald E. Staunton and Stephen W. Fesik

Journal:

Proceedings of the National Academy of Sciences

Year:

1998

Language:

english

File:

PDF, 1.69 MB

english, 1998

15

Fragment-based screening of programmed death ligand 1 (PD-L1)

Perry, Evan, Mills, Jonathan J., Zhao, Bin, Wang, Feng, Sun, Qi, Christov, Plamen P., Tarr, James C., Rietz, Tyson A., Olejniczak, Edward T., Lee, Taekyu, Fesik, Stephen

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2019

File:

PDF, 798 KB

2019

16

The Bcl-2 inhibitor ABT-263 enhances the response of multiple chemotherapeutic regimens in hematologic tumors in vivo

Scott Ackler, Michael J. Mitten, Kelly Foster, Anatol Oleksijew, Marion Refici, Stephen K. Tahir, Yu Xiao, Christin Tse, David J. Frost, Stephen W. Fesik, Saul H. Rosenberg, Steven W. Elmore, Alexande

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2010

Language:

english

File:

PDF, 683 KB

english, 2010

17

Synthesis and FKBP binding of small molecule mimics of the tricarbonyl region of FK506

Gary T. Wang, Ben Lane, Stephen W. Fesik, Andrew Petros, Jay Luly, Grant A. Krafft

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1994

Language:

english

File:

PDF, 433 KB

english, 1994

18

Structural basis for IL-4 receptor phosphopeptide recognition by thelRS-1 PTB domain

Zhou, Ming-Ming, Huang, Baohua, Olejniczak, Edward T., Meadows, Robert P., Shuker, Suzanne B., Miyazaki, Masaya, Trüb, Thomas, Shoelson, Steven E., Fesik, Stephen W.

Journal:

Natural Structural Biology

Year:

1996

File:

PDF, 958 KB

1996

19

Side chain and backbone assignments in isotopically labeled proteins from two heteronuclear triple resonance experiments

Timothy M. Logan, Edward T. Olejniczak, Robert X. Xu, Stephen W. Fesik

Journal:

Year:

1992

Language:

english

File:

PDF, 563 KB

english, 1992

20

1H,13C and 15N backbone assignments of cyclophilin when bound to cyclosporin A (CsA) and preliminary structural characterization of the CsA binding site

Placido Neri, Robert Meadows, Gerd Gemmecker, Edward Olejniczak, David Nettesheim, Timothy Logan, Robert Simmer, Rosalind Helfrich, Thomas Holzman, Jean Severin, Stephen Fesik

Journal:

Year:

1991

Language:

english

File:

PDF, 695 KB

english, 1991

21

NMR-Driven Discovery of Benzoylanthranilic Acid Inhibitors of Far Upstream Element Binding Protein Binding to the Human Oncogene c-myc Promoter

Huth, Jeffrey R., Yu, Liping, Collins, Irene, Mack, Jamey, Mendoza, Renaldo, Isaac, Binumol, Braddock, Demetrios T., Muchmore, Steven W., Comess, Kenneth M., Fesik, Stephen W., Clore, G. Marius, Leven

Journal:

Journal of Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 350 KB

english, 2004

22

Solution Structure of a Low Molecular Weight Protein Tyrosine Phosphatase

Logan, Timothy M., Zhou, Ming-Ming, Nettesheim, David G., Meadows, Robert P., Van Etten, Robert L., Fesik, Stephen W.

Journal:

Year:

1994

Language:

english

File:

PDF, 2.38 MB

english, 1994

23

Renin inhibitors. Design and synthesis of a new class of conformationally restricted analogs of angiotensinogen

Sham, Hing L., Bolis, Giorgio, Stein, Herman H., Fesik, Stephen W., Marcotte, Patrick A., Plattner, Jacob J., Rempel, Cheryl A., Greer, Jonathan

Journal:

Journal of Medicinal Chemistry

Year:

1988

Language:

english

File:

PDF, 1.69 MB

english, 1988

24

Solution Structure of the Shc SH2 Domain Complexed with a Tyrosine-Phosphorylated Peptide from the T-Cell Receptor

Ming-Ming Zhou, Robert P. Meadows, Timothy M. Logan, Ho Sup Yoon, Warren S. Wade, Kodimangalam S. Ravichandran, Steven J. Burakoff and Stephen W. Fesik

Journal:

Proceedings of the National Academy of Sciences

Year:

1995

Language:

english

File:

PDF, 1.10 MB

english, 1995

25

The Secondary Structure of the Ets Domain of Human Fli-1 Resembles that of the Helix-Turn-Helix DNA-Binding Motif of the Escherichia coli Catabolite Gene Activator Protein

Heng Liang, Edward T. Olejniczak, Xiaohong Mao, David G. Nettesheim, Liping Yu, Craig B. Thompson and Stephen W. Fesik

Journal:

Proceedings of the National Academy of Sciences

Year:

1994

Language:

english

File:

PDF, 1.09 MB

english, 1994

26

Targeting WDR5: A WINning Anti-Cancer Strategy?

Aho, Erin R, Weissmiller, April M, Fesik, Stephen W, Tansey, William P

Journal:

Epigenetics Insights

Year:

2019

Language:

english

File:

PDF, 183 KB

english, 2019

27

Application of isotope-filtered 2D NOE experiments in the conformational analysis of atrial natriuretic factor(7–23)

Stephen W Fesik, Robert T Gampe Jr., Todd W Rockway

Journal:

Journal of Magnetic Resonance (1969)

Year:

1969

Language:

english

File:

PDF, 373 KB

english, 1969

28

Structure and ligand recognition of the phosphotyrosine binding domain of Shc

Zhou, Ming-Ming, Ravichandran, Kodimangalam S., Olejniczak, Edward T., Petros, Andrew M., Meadows, Robert P., Sattler, Michael, Harlan, John E., Wade, Warren S., Burakoff, Steven J., Fesik, Stephen W.

Journal:

Year:

1995

File:

PDF, 2.85 MB

1995

29

Lithium chloride perturbation of cis-trans peptide bond equilibria: effect on conformational equilibria in cyclosporin A and on time-dependent inhibition of cyclophilin

Kofron, James L., Kuzmic, Petr, Kishore, Vimal, Gemmecker, Gerd, Fesik, Stephen W., Rich, Daniel H.

Journal:

Journal of the American Chemical Society

Year:

1992

Language:

english

File:

PDF, 802 KB

english, 1992

30

Fragment-based drug discovery using NMR spectroscopy

Harner, Mary J., Frank, Andreas O., Fesik, Stephen W.

Journal:

Journal of Biomolecular NMR

Year:

2013

Language:

english

File:

PDF, 410 KB

english, 2013

31

NMR Study of the Possible Interaction in Solution of Angiotensin II with a Peptide Encoded by Angiotensin II Complementary RNA

Hugh L. Eaton, Richard E. Austin, Stephen W. Fesik and Stephen F. Martin

Journal:

Proceedings of the National Academy of Sciences

Year:

1989

Language:

english

File:

PDF, 464 KB

english, 1989

32

NMR Analysis of the Structure and Metal Sequestering Properties of Metallothioneins

Catherine T. Hunt, Yvan Boulanger, Stephen W. Fesik and Ian M. Armitage

Journal:

Environmental Health Perspectives

Year:

1984

Language:

english

File:

PDF, 2.46 MB

english, 1984

33

14-3-3 Proteins and Survival Kinases Cooperate to Inactivate BAD by BH3 Domain Phosphorylation

Sandeep Robert Datta, Alex Katsov, Linda Hu, Andrew Petros, Stephen W. Fesik, Michael B. Yaffe, Michael E. Greenberg

Journal:

Year:

2000

Language:

english

File:

PDF, 399 KB

english, 2000

34

A practical method for uniform isotopic labeling of recombinant proteins in mammalian cells

Hansen, Andrew P., Petros, Andrew M., Mazar, Andrew P., Pederson, Terry M., Rueter, Annemarie, Fesik, Stephen W.

Journal:

Year:

1992

Language:

english

File:

PDF, 613 KB

english, 1992

35

An approach for studying the active site of enzyme/inhibitor complexes using deuterated ligands and 2D NOE difference spectroscopy

Fesik, Stephen W., Zuiderweg, Erik R. P.

Journal:

Journal of the American Chemical Society

Year:

1989

Language:

english

File:

PDF, 435 KB

english, 1989

36

NMR structure-based drug design

Stephen W. Fesik

Journal:

Journal of Biomolecular NMR

Year:

1993

Language:

english

File:

PDF, 619 KB

english, 1993

37

Promoting apoptosis as a strategy for cancer drug discovery

Fesik, Stephen W.

Journal:

Nature Reviews Cancer

Year:

2005

Language:

english

File:

PDF, 138 KB

english, 2005

38

A liquid crystalline medium for measuring residual dipolar couplings over a wide range of temperatures

Hong Wang, Matthias Eberstadt, Edward T. Olejniczak, Robert P. Meadows, Stephen W. Fesik

Journal:

Journal of Biomolecular NMR

Year:

1998

Language:

english

File:

PDF, 52 KB

english, 1998

39

Defining the p53 DNA-binding domain/Bcl-xL-binding interface using NMR

Andrew M Petros, Angelo Gunasekera, Nan Xu, Edward T Olejniczak, Stephen W Fesik

Journal:

Year:

2004

Language:

english

File:

PDF, 246 KB

english, 2004

40

Discovery and Structure−Activity Relationship of Oxalylarylaminobenzoic Acids as Inhibitors of Protein Tyrosine Phosphatase 1B

Liu, Gang, Szczepankiewicz, Bruce G., Pei, Zhonghua, Janowick, David A., Xin, Zhili, Hajduk, Philip J., Abad-Zapatero, Cele, Liang, Heng, Hutchins, Charles W., Fesik, Stephen W., Ballaron, Steve J., S

Journal:

Journal of Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 267 KB

english, 2003

41

Interaction of the oncoprotein transcription factor MYC with its chromatin cofactor WDR5 is essential for tumor maintenance

Thomas, Lance R., Adams, Clare M., Wang, Jing, Weissmiller, April M., Creighton, Joy, Lorey, Shelly L., Liu, Qi, Fesik, Stephen W., Eischen, Christine M., Tansey, William P.

Journal:

Proceedings of the National Academy of Sciences

Year:

2019

File:

PDF, 1.83 MB

2019

42

Structural biology of the Bcl-2 family of proteins

Andrew M. Petros, Edward T. Olejniczak, Stephen W. Fesik

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Year:

2004

Language:

english

File:

PDF, 1.63 MB

english, 2004

43

Druggability Indices for Protein Targets Derived from NMR-Based Screening Data

Hajduk, Philip J., Huth, Jeffrey R., Fesik, Stephen W.

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 322 KB

english, 2005

44

NMR studies of an FK-506 analog, [U-carbon-13]ascomycin, bound to FK-506-binding protein

Petros, Andrew M., Gemmecker, Gerd, Neri, Placido, Olejniczak, Edward T., Nettesheim, David, Xu, Robert X., Gubbins, Earl G., Smith, Harriet, Fesik, Stephen W.

Journal:

Journal of Medicinal Chemistry

Year:

1992

Language:

english

File:

PDF, 2.16 MB

english, 1992

45

Resolving Resonance Overlap in the NMR Spectra of Proteins from Differential Lanthanide-Induced Shifts

Sattler, Michael, Fesik, Stephen W.

Journal:

Journal of the American Chemical Society

Year:

1997

Language:

english

File:

PDF, 89 KB

english, 1997

46

Deoxydative substitution of pyridine 1-oxides. 18. Tetrahydropyridines from 3-picoline 1-oxide and tert-butyl and 1-adamantyl mercaptan in acetic anhydride. Structural elucidation by long range 2D J(C-H) resolved NMR spectroscopy

Prachayasittikul, Supaluk, Kokosa, John M., Bauer, Ludwig, Fesik, Stephen W.

Journal:

Journal of Organic Chemistry

Year:

1985

Language:

english

File:

PDF, 752 KB

english, 1985

47

Heteronuclear three-dimensional NMR spectroscopy of isotopically labelled biological macromolecules

Fesik, Stephen W., Zuiderweg, Erik R. P.

Journal:

Quarterly Reviews of Biophysics

Year:

1990

Language:

english

File:

PDF, 1.60 MB

english, 1990

48

Discovery of Sulfonamide-Derived Agonists of SOS1-Mediated Nucleotide Exchange on RAS Using Fragment-Based Methods

Sarkar, Dhruba, Olejniczak, Edward T, Phan, Jason, Coker, Jesse A, Sai, Jiqing, Arnold, Allison L, Beesetty, Yugandhar, Waterson, Alex G., Fesik, Stephen W.

Journal:

Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 958 KB

2020

49

Effects of anesthetics on sulfate transport in the red cell

Alexandros Makriyannis, Stephen W. Fesik

Journal:

Journal of Neuroscience Research

Year:

1980

Language:

english

File:

PDF, 435 KB

english, 1980

50

Increased NOEs for small molecules using mixed solvents

Stephen W. Fesik, Edward T. Olejniczak

Journal:

Magnetic Resonance in Chemistry

Year:

1987

Language:

english

File:

PDF, 248 KB

english, 1987

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